Publikationen der Abteilung für Strukturbiologie

Lee, Y.; Jin, C.; Ohgaki, R.; Xu, M.; Ogasawara, S.; Warshamanage, R.; Yamashita, K.; Murshudov, G.; Nureki, O.; Murata, T. et al.; Kanai, Y.: Structural basis of anticancer drug recognition and amino acid transport by LAT1. Nature Communications 16, 1635 (2025)

Introini, B.; Hahn, A.; Kühlbrandt, W.: Cryo-EM structure of the NDH-PSI-LHCI supercomplex from Spinacia oleracea. Nature Structural & Molecular Biology (2025)

Periasamy, A.; Ornelas, P.; Bausewein, T.; Mitchell, N.; Zhao, J.; Quinn, L. M.; Kuehlbrandt, W.; Gulbis, J. M.: Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM. IUCrJ 12 (1) (2025)

Wilm, M.: Nanoelectrospray based synthesis of large, transportable membranes with integrated membrane proteins. Scientific Reports 14, 25192 (2024)

Dietrich, L.; Agip, A.-N. A.; Kunz, C.; Schwarz, A.; Kühlbrandt, W.: In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells. Science 385 (6713), S. 1086 - 1090 (2024)

Schneider, S.; Kühlbrandt, W.; Yildiz, Ö.: Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism. Structure 32 (7), S. 979 - 988.e4 (2024)

Adolph, C.; Cheung, C.-Y.; McNeil, M. B.; Jowsey, W. J.; Williams, Z. C.; Hards, K.; Harold, L. K.; Aboelela, A.; Bujaroski, R. S.; Buckley, B. J. et al.; Tyndall, J. D. A.; Li, Z.; Langer, J. D.; Preiss, L.; Meier, T.; Steyn, A. J. C.; Rhee, K. Y.; Berney, M.; Kelso, M. J.; Cook, G. M.: A dual-targeting succinate dehydrogenase and F₁F_o-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology 31, S. 683 - 698.e7 (2024)

Aziz, I.; Kayastha, K.; Kaltwasser, S.; Vonck, J.; Welsch, S.; Murphy, B. J.; Kahnt, J.; Wu, D.; Wagner, T.; Shima, S. et al.; Ermler, U.: Structural and mechanistic basis of the central energy-converting methyltransferase complex of methanogenesis. PNAS 121 (14), e2315568121 (2024)

Lasham, J.; Djurabekova, A.; Zickermann, V.; Vonck, J.; Sharma, V.: Role of Protonation States in the Stability of Molecular Dynamics Simulations of High-Resolution Membrane Protein Structures. The Journal of Physical Chemistry B 128 (10), S. 2304 - 2316 (2024)

Laube, E.; Schiller, J.; Zickermann, V.; Vonck, J.: Using cryo-EM to understand the assembly pathway of respiratory complex I. Acta Crystallographica Section D: Structural Biology 80, S. 159 - 173 (2024)

Centola, M.; Poppleton, E.; Ray, S.; Centola, M.; Welty, R.; Valero, J.; Walter, N. G.; Šulc, P.; Famulok, M.: A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower. Nature Nanotechnology 19 (2), S. 226 - 236 (2024)

Gewering, T.; Waghray, D.; Parey, K.; Jung, H.; Tran, N. N. B.; Zapata, J.; Zhao, P.; Chen, H.; Januliene, D.; Hummer, G. et al.; Urbatsch, I.; Moeller, A.; Zhang, Q.: Tracing the substrate translocation mechanism in P-glycoprotein. eLife 12, RP90174 (2024)

Braun, H.-P.; Klusch, N.: Promotion of oxidative phosphorylation by complex I-anchored carbonic anhydrases? Trends in Plant Science 29 (1), S. 64 - 71 (2024)

Lasham, J.; Djurabekova, A.; Kolypetris, G.; Zickermann, V.; Vonck, J.; Sharma, V.: Assessment of amino acid charge states based on cryo-electron microscopy and molecular dynamics simulations of respiratory complex I. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1866 (1), 149512 (2024)

Hau, J.-L.; Kaltwasser, S.; Muras, V.; Casutt, M. S.; Vohl, G.; Claußen, B.; Steffen, W.; Leitner, A.; Bill, E.; Cutsail, G. E. et al.; DeBeer, S.; Vonck, J.; Steuber, J.; Fritz, G.: Conformational coupling of redox-driven Na⁺-translocation in Vibrio cholerae NADH:quinone oxidoreductase. Nature Structural & Molecular Biology 30 (11), S. 1686 - 1694 (2023)

Ornelas, P.; Bausewein, T.; Martin, J.; Morgner, N.; Nussberger, S.; Kühlbrandt, W.: Two conformations of the Tom20 preprotein receptor in the TOM holo complex. Proceedings of the National Academy of Sciences of the United States of America 120 (34), e2301447120 (2023)

Fuss, M. F.; Wieferig, J.-P.; Corey, R. A.; Hellmich, Y.; Tascón, I.; Sousa, J. S.; Stansfeld, P. J.; Vonck, J.; Hänelt, I.: Cyclic di-AMP traps proton-coupled K⁺ transporters of the KUP family in an inward-occluded conformation. Nature Communications 14, 3683 (2023)

Klusch, N.; Dreimann, M.; Senkler, J.; Rugen, N.; Kühlbrandt, W.; Braun, H.-P.: Cryo-EM structure of the respiratory I + III₂ supercomplex from Arabidopsis thaliana at 2 Å resolution. Nature Plants 9, S. 142 - 156 (2023)

Wieferig, J.-P.; Kühlbrandt, W.: Analysis of the conformational heterogeneity of the Rieske iron–sulfur protein in complex III₂ by cryo-EM. IUCrJ 10 (1), S. 27 - 37 (2023)

Laube, E.; Meier-Credo, J.; Langer, J. D.; Kühlbrandt, W.: Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Science Advances 8 (47), eadc9952 (2022)