Julian Langer: Mass Spectrometry – Research Group Publications

Herhaus, L.; Gestal-Mato, U.; Eapen, V. V.; Mačinković, I.; Bailey, H. J.; Prieto-Garcia, C.; Misra, M.; Jacomin, A.-C.; Ammanath, A. V.; Bagarić, I. et al.; Michaelis, J.; Vollrath, J.; Bhaskara, R. M.; Bündgen, G.; Covarrubias-Pinto, A.; Husnjak, K.; Zöller, J.; Gikandi, A.; Ribičić, S.; Bopp, T.; van der Heden van Noort, G. J.; Langer, J. D.; Weigert, A.; Harper, J. W.; Mancias, J. D.; Đikić, I.: IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion. Cell 187 (2024)

Laub, V.; Nan, E.; Elias, L.; Donaldson, I. J.; Bentsen, M.; Rusling, L. A.; Schupp, J.; Lun, J. H.; Plate, K. H.; Looso, M. et al.; Langer, J. D.; Günther, S.; Bobola, N.; Schulte, D.: Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4. Nucleic Acids Research, gkae864 (2024)

Kuhn, B. T.; Zöller, J.; Zimmermann, I.; Gemeinhardt, T.; Özkul, D. H.; Langer, J. D.; Seeger, M. A.; Geertsma, E. R.: Interdomain-linkers control conformational transitions in the SLC23 elevator transporter UraA. Nature Communications 15, 7518 (2024)

Khusainov, I.; Romanov, N.; Goemans, C.; Turoňová, B.; Zimmerli, C. E.; Welsch, S.; Langer, J. D.; Typas, A.; Beck, M.: Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction. Nature Communications 15, 4783 (2024)

Adolph, C.; Cheung, C.-Y.; McNeil, M. B.; Jowsey, W. J.; Williams, Z. C.; Hards, K.; Harold, L. K.; Aboelela, A.; Bujaroski, R. S.; Buckley, B. J. et al.; Tyndall, J. D. A.; Li, Z.; Langer, J. D.; Preiss, L.; Meier, T.; Steyn, A. J. C.; Rhee, K. Y.; Berney, M.; Kelso, M. J.; Cook, G. M.: A dual-targeting succinate dehydrogenase and F₁F_o-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology 31, pp. 683 - 698.e7 (2024)

Altincekic, N.; Jores, N.; Löhr, F.; Richter, C.; Ehrhardt, C.; Blommers, M. J. J.; Berg, H.; Öztürk, S.; Gande, S. L.; Linhard, V. et al.; Orts, J.; Abi Saad, M. J.; Bütikofer, M.; Kaderli, J.; Karlsson, B. G.; Brath, U.; Hedenström, M.; Gröbner, G.; Sauer, U. H.; Perrakis, A.; Langer, J. D.; Banci, L.; Cantini, F.; Fragai, M.; Grifagni, D.; Barthel, T.; Wollenhaupt, J.; Weiss, M. S.; Robertson, A.; Bax, A.; Sreeramulu, S.; Schwalbe, H.: Targeting the Main Protease (M^pro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS Chemical Biology 19 (2), pp. 563 - 574 (2024)

Bapat, O.; Purimetla, T.; Kruessel, S.; Shah, M.; Fan, R.; Thum, C.; Rupprecht, F. A.; Langer, J. D.; Rangaraju, V.: VAP spatially stabilizes dendritic mitochondria to locally support synaptic plasticity. Nature Communications 15 (1), 205 (2024)

van Oostrum, M.; Blok, T. M.; Giandomenico, S. L.; tom Dieck, S.; Tushev, G.; Fürst, N.; Langer, J. D.; Schuman, E. M.: The proteomic landscape of synaptic diversity across brain regions and cell types. Cell 186 (24), pp. 5411 - 5427.e23 (2023)

Meier-Credo, J.; Heiniger, B.; Schori, C.; Rupprecht, F.; Michel, H.; Ahrens, C. A.; Langer, J. D.: Detection of Known and Novel Small Proteins in Pseudomonas stutzeri Using a Combination of Bottom-Up and Digest-Free Proteomics and Proteogenomics. Analytical Chemistry 95, pp. 11892 - 11900 (2023)

Lyratzakis, A.; Meier-Credo, J.; Langer, J. D.; Tsiotis, G.: Insights into the sulfur metabolism of Chlorobaculum tepidum by label-free quantitative proteomics. Proteomics 23 (10), 2200138 (2023)

Sun, C.; Desch, K.; Nassim-Assir, B.; Giandomenico, S. L.; Nemcova, P.; Langer, J. D.; Schuman, E. M.: An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses. Science 380 (6647), eadf2018 (2023)

Lambertz, J.; Meier-Credo, J.; Kucher, S.; Bordignon, E.; Langer, J. D.; Nowaczyk, M. M.: Isolation of a novel heterodimeric PSII complex via strep-tagged PsbO. Biochimica et Biophysica Acta, Bioenergetics 1864 (2), 148953 (2023)

Sprankel, L.; Vizaragga, D.; Martín, J.; Manger, S.; Meier-Credo, J.; Marcos, M.; Julve, J.; Rotllan, N.; Scheffer, M. P.; Escolà-Gil, J. C. et al.; Langer, J. D.; Piñol, J.; Fita, I.; Frangakis, A. S.: Essential protein P116 extracts cholesterol and other indispensable lipids for Mycoplasmas. Nature Structural and Molecular Biology 30 (3), pp. 321 - 329 (2023)

Laube, E.; Meier-Credo, J.; Langer, J. D.; Kühlbrandt, W.: Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum. Science Advances 8 (47), eadc9952 (2022)

Zöller, J.; Hong, S.; Eisinger, M. L.; Anderson, M.; Radloff, M.; Desch, K.; Gennis, R.; Langer, J. D.: Ligand binding and conformational dynamics of the E. coli nicotinamide nucleotide transhydrogenase revealed by hydrogen/deuterium exchange mass spectrometry. Computational and Structural Biotechnology Journal 20, pp. 5430 - 5439 (2022)

Meier-Credo, J.; Preiss, L.; Wüllenweber, I.; Resemann, A.; Nordmann, C.; Zabret, J.; Suckau, D.; Michel, H.; Nowacyk, M. M.; Meier, T. et al.; Langer, J. D.: Top-Down Identification and Sequence Analysis of Small Membrane Proteins Using MALDI-MS/MS. Journal of the American Society for Mass Spectrometry 33 (7), pp. 1293 - 1302 (2022)

Desch, K.; Schuman, E. M.; Langer, J. D.: Quantifying phosphorylation dynamics in primary neuronal cultures using LC-MS/MS. STAR Protocols 3 (1), 101063 (2022)

Seidel, M.; Becker, A.; Pereira, F.; Landry, J. J. M.; de Azevedo, N. T. D.; Fusco, C. M.; Kaindl, E.; Romanov, N.; Baumbach, J.; Langer, J. D. et al.; Schuman, E. M.; Patil, K. R.; Hummer, G.; Benes, V.; Beck, M.: Co-translational assembly orchestrates competing biogenesis pathways. Nature Communications 13, 1224 (2022)

Ahrens, C. H.; Wade, J. T.; Champion, M. M.; Langer, J. D.: A Practical Guide to Small Protein Discovery and Characterization using Mass Spectrometry. Journal of Bacteriology 204 (1), e0035321 (2022)

Luciano, V.; Proschak, E.; Langer, J. D.; Knapp, S.; Heering, J.; Marschalek, R.: Closantel is an allosteric inhibitor of human Taspase1. iScience 24 (12), e103524 (2021)

Fusco, C. M.; Desch, K.; Dörrbaum, A. R.; Wang, M.; Staab, A.; Chan, I. C. W.; Vail, E.; Villeri, V.; Langer, J. D.; Schuman, E. M.: Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins. Nature Communications 12 (1), 6127 (2021)

Desch, K.; Langer, J. D.; Schuman, E. M.: Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling. Cell Reports 36 (8), 109583 (2021)

Zabret, J.; Bohn, S.; Schuller, S. K.; Arnolds, O.; Möller, M.; Meier-Credo, J.; Liauw, P.; Chan, A.; Tajkhorshid, E.; Langer, J. D. et al.; Stoll, R.; Krieger-Liszkay, A.; Engel, B. D.; Rudack , T.; Schuller, J. M.; Nowaczyk , M. M.: Structural insights into photosystem II assembly. Nature Plants 7, pp. 524 - 538 (2021)

Ross, A. B.; Langer, J. D.; Jovanovic, M.: Proteome Turnover in the Spotlight: Approaches, Applications, and Perspectives. Molecular and Cellular Proteomics 20, 100016 (2021)

Lyratzakis, A.; Valsamidis, G.; Kanavaki, I.; Nikolaki , A.; Rupprecht, F. A.; Langer, J. D.; Tsiotis, G.: Proteomic Characterization of the Pseudomonas sp. Strain phDV1 Response to Monocyclic Aromatic Compounds. Proteomics 21 (2), e2000003 (2021)

Schulte, L.; Mao, J.; Reitz, J.; Sreeramulu, S.; Kudlinzki, D.; Hodirnau, V.-V.; Meier-Credo, J.; Saxena, K.; Buhr, F.; Langer, J. D. et al.; Blackledge, M.; Frangakis, A. S.; Glaubitz, C.; Schwalbe, H.: Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nature Communications 11 (1), 5569 (2020)

Neuhaus, A.; Selvaraj, M.; Salzer, R.; Langer, J. D.; Kruse, K.; Kirchner, L.; Sanders, K.; Daum, B.; Averhoff, B.; Gold, V.: Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium. Nature Communications 11, 2231 (2020)

Altincekic, N.; Löhr, F.; Meier-Credo, J.; Langer, J. D.; Hengesbach, M.; Richter, C.; Schwalbe, H.: Site-Specific Detection of Arginine Methylation in Highly Repetitive Protein Motifs of Low Sequence Complexity by NMR. Journal of the American Chemical Society 142 (16), pp. 7647 - 7654 (2020)

Dörrbaum, A. R.; Alvarez-Castelao, B.; Nassim-Assir, B.; Langer, J. D.; Schuman, E. M.: Proteome dynamics during homeostatic scaling in cultured neurons. eLife 9, e52939 (2020)

Biever, A.; Glock, C.; Tushev, G.; Ciirdaeva, E.; Dalmay, T.; Langer, J. D.; Schuman, E. M.: Monosomes actively translate synaptic mRNAs in neuronal processes. Science 367 (6477), eaay4991, p. 526 (2020)

Dörrbaum , A. R.; Schuman, E. M.; Langer, J. D.: Dynamic SILAC to Determine Protein Turnover in Neurons and Glia. In: SILAC: Methods and Protocols, Vol. 2603, pp. 1 - 18 (Ed. Luque-Garcia, J. L.). Springer, New York, NY (2023)