Publications of Sonja Welsch

Kreysing, J. P.; Heidari, M.; Zila, V.; Cruz-León, S.; Obarska-Kosinska, A.; Laketa, V.; Rohleder, L.; Welsch, S.; Köfinger, J.; Turoňová, B. et al.; Hummer, G.; Kräusslich, H.-G.; Beck, M.: Passage of the HIV capsid cracks the nuclear pore. Cell 188 (4), pp. 930 - 943.e21 (2025)

Licheva, M.; Pflaum, J.; Babic, R.; Mancilla, H.; Elsässer, J.; Boyle, E.; Hollenstein, D. M.; Jimenez-Niebla, J.; Pleyer, J.; Heinrich, M. et al.; Wieland, F.-G.; Brenneisen, J.; Eickhorst, C.; Brenner, J.; Jiang, S.; Hartl, M.; Welsch, S.; Hunte, C.; Timmer, J.; Wilfling, F.; Kraft, C.: Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy. Nature Cell Biology 27 (2), pp. 283 - 297 (2025)

Liu, J.; Corroyer-Dulmont, S.; Pražák, V.; Khusainov, I.; Bahrami, K.; Welsch, S.; Vasishtan, D.; Obarska-Kosińska, A.; Thorkelsson, S. R.; Grünewald, K. et al.; Quemin, E. R. J.; Turoňová, B.; Locker, J. K.: The palisade layer of the poxvirus core is composed of flexible A10 trimers. Nature Structural & Molecular Biology 31, pp. 1105 - 1113 (2024)

Ri, K.; Weng, T.-H.; Claveras Cabezudo, A.; Jösting, W.; Zhang, Y.; Bazzone, A.; Leong, N. C. P.; Welsch, S.; Doty, R. T.; Gursu, G. et al.; Lim, T. J. Y.; Schmidt, S. L.; Abkowitz, J. L.; Hummer, G.; Wu, D.; Nguyen, L. N.; Safarian, S.: Molecular mechanism of choline and ethanolamine transport in humans. Nature 630, pp. 501 - 508 (2024)

Khusainov, I.; Romanov, N.; Goemans, C.; Turoňová, B.; Zimmerli, C. E.; Welsch, S.; Langer, J. D.; Typas, A.; Beck, M.: Bactericidal effect of tetracycline in E. coli strain ED1a may be associated with ribosome dysfunction. Nature Communications 15, 4783 (2024)

Tuijtel, M.; Cruz-León, S.; Kreysing, J. P.; Welsch, S.; Hummer, G.; Beck, M.; Turoňová, B.: Thinner is not always better: Optimizing cryo-lamellae for subtomogram averaging. Science Advances 10 (17), eadk6285 (2024)

Schulz, V.; Steinhilper, R.; Oltmanns, J.; Freibert, S.-A.; Krapoth, N.; Linne, U.; Welsch, S.; Hoock, M. H.; Schünemann, V.; Murphy, B. J. et al.; Lill, R.: Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2. Nature Communications 15, 3269 (2024)

Aziz, I.; Kayastha, K.; Kaltwasser, S.; Vonck, J.; Welsch, S.; Murphy, B. J.; Kahnt, J.; Wu, D.; Wagner, T.; Shima, S. et al.; Ermler, U.: Structural and mechanistic basis of the central energy-converting methyltransferase complex of methanogenesis. PNAS 121 (14), e2315568121 (2024)

Wu, D.; Mehdipour, A. R.; Finke, F.; Goojani, H. G.; Groh, R. R.; Grund, T. N.; Reichhart, T. M. B.; Zimmermann, R.; Welsch, S.; Bald, D. et al.; Shepherd, M.; Hummer, G.; Safarian, S.: Dissecting the conformational complexity and mechanism of a bacterial heme transporter. Nature Chemical Biology 19 (8), pp. 992 - 1003 (2023)

Xing, H.; Taniguchi, R.; Khusainov, I.; Kreysing, J. P.; Welsch, S.; Turoňová, B.; Beck, M.: Translation dynamics in human cells visualized at high resolution reveal cancer drug action. Science 381 (6653), pp. 70 - 75 (2023)

Xie, H.; Lyratzakis, A.; Khera, R.; Koutantou, M.; Welsch, S.; Michel, H.; Tsiotis, G.: Cryo-EM structure of the whole photosynthetic reaction center apparatus from the green sulfur bacterium Chlorobaculum tepidum. Proceedings of the National Academy of Sciences of the United States of America 120 (5), e2216734120 (2023)

Grund, T. N.; Kabashima, Y.; Kusumoto, T.; Wu, D.; Welsch, S.; Sakamoto, J.; Michel, H.; Safarian, S.: The cryoEM structure of cytochrome bd from C. glutamicum provides novel insights into structural properties of actinobacterial terminal oxidases. Frontiers in Chemistry (2023)

Hoffmann, P. C.; Kreysing, J. P.; Khusainov, I.; Tuijtel, M.; Welsch, S.; Beck, M.: Structures of the eukaryotic ribosome and its translational states in situ. Nature Communications 13, 7435 (2022)

Schleker, E. S. M.; Buschmann, S.; Xie, H.; Welsch, S.; Michel, H.; Reinhart, C.: Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules. Proceedings of the National Academy of Sciences of the United States of America 126 (43), pp. 8646 - 8654 (2022)

Khera, R.; Mehdipour, A. R.; Bolla, J. R.; Kahnt, J.; Welsch, S.; Ermler, U.; Münke, C.; Robinson, C. V.; Hummer, G.; Xie, H. et al.; Michel, H.: Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism. The EMBO Journal 41 (18), e109990 (2022)

Kayastha, K.; Katsyv, A.; Himmrich, C.; Welsch, S.; Schuller, J. M.; Ermler, U.; Müller, V.: Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex. eLife 11, e77095 (2022)

Grund, T. N.; Radloff, M.; Wu, D.; Goojani, H. G.; Witte, L. F.; Jösting, W.; Buschmann, S.; Müller, H.; Elamri, I.; Welsch, S. et al.; Schwalbe, H.; Michel, H.; Bald, D.; Safarian, S.: Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 118 (50), e2114013118 (2021)

Kolbe, F.; Safarian, S.; Piórek, Ż.; Welsch, S.; Müller, H.; Michel, H.: Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase. Nature Communications 12, 6903 (2021)

Safarian, S.; Opel-Reading, H. K.; Wu, D.; Mehdipour, A. R.; Hards, K.; Harold, L. H.; Radloff, M.; Stewart, I.; Welsch, S.; Hummer, G. et al.; Cook, G. M.; Krause, K. L.; Michel, H.: The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. Nature Communications 12 (1), 5236 (2021)

Turoňová, B.; Sikora, M.; Schürmann, C.; Hagen, W. J. H.; Welsch, S.; Blanc, F. E. C.; von Bülow, S.; Gecht, M.; Bagola, K.; Hörner, C. et al.; van Zandbergen, G.; Landry, J.; de Azevedo, N. T. D.; Mosalaganti, S.; Schwarz, A.; Covino, R.; Mühlebach, M. D.; Hummer, G.; Krijnse Locker, J.; Beck, M.: In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges. Science 370 (6513), pp. 203 - 208 (2020)

Wu, D.; Grund, T. N.; Welsch, S.; Mills, D.; Michel, M.; Safarian, S.; Michel, H.: Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America 117 (35), 202008111, pp. 21281 - 21287 (2020)