Publikationen von Christine Ziegler

Koshy, C.; Ziegler, C.: Structural insights into functional lipid–protein interactions in secondary transporters. Biochimica et Biophysica Acta (BBA) - General Subjects 1850 (3), S. 476 - 487 (2015)

Schweikhard, E. S.; Burckhardt, B. C.; Joos, F.; Fenollar-Ferrer, C.; Forrest, L. R.; Kempson, S. A.; Ziegler, C.: Role of N-glycosylation in renal betaine transport. Biochemical Journal 470 (2), S. 169 - 179 (2015)

Spindler, P. E.; Waclawska, I.; Endeward, B.; Plackmeyer, J.; Ziegler, C.; Prisner, T. F.: Carr−Purcell Pulsed Electron Double Resonance with Shaped Inversion Pulses. The Journal of Physical Chemistry 6 (21), S. 4331 - 4335 (2015)

Perez, C.; Faust, B.; Mehdipour, A. R.; Francesconi, K. A.; Forrest, L. R.; Ziegler, C.: Substrate-bound outward-open state of the betaine transporter BetP provides insights into Na⁺ coupling. Nature Communications 5, 4231 (2014)

Sand, M.; Stahl, J.; Waclawska, I.; Ziegler, C.; Averhoff, B.: Identification of an osmo-dependent and an osmo-independent choline transporter in Acinetobacter baylyi: implications in osmostress protection and metabolic adaptation. Environmental Microbiology 16 (6), S. 1490 - 1502 (2014)

Keller, R.; Ziegler, C.; Schneider, D.: When two turn into one: evolution of membrane transporters from half modules. Biological Chemistry 395 (12), S. 1379 - 1388 (2014)

Schweikhard, E. S.; Kempson, S. A.; Ziegler, C.; Burckhardt, B. C.: Mutation of a single threonine in the cytoplasmic NH2 terminus disrupts trafficking of renal betaine-GABA transporter 1 during hypertonic stress. American Journal of Physiology - Renal Physiology 307 (1), S. F107 - F115 (2014)

Koshy, C.; Schweikhard, E. S.; Gärtner, R. M.; Perez, C.; Yildiz, Ö.; Ziegler, C.: Structural evidence for functional lipid interactions in the betaine transporter BetP. The EMBO Journal 32 (23), S. 3096 - 3105 (2013)

Perez, C.; Ziegler, C.: Mechanistic aspects of sodium-binding sites in LeuT-like fold symporters. Biological Chemistry 394 (5), S. 641 - 648 (2013)

Korkmaz, F.; Ressl, S.; Ziegler, C.; Mäntele, W.: K⁺-induced conformational changes in the trimeric betaine transporter BetP monitored by ATR-FTIR spectroscopy. Biochimica et Biophysica Acta-Biomembranes 1828 (4), S. 1181 - 1191 (2013)

Khafizov, K.; Perez, C.; Koshy, C.; Quick, M.; Fendler, K.; Ziegler, C.; Forrest, L. R.: Investigation of the sodium binding sites in the betaine transporter BetP. Proceedings of the National Academy of Sciences of the United States of America 109 (44), S. E3035 - E3045 (2012)

Perez, C.; Koshy, C.; Yildiz, Ö.; Ziegler, C.: Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP. Nature 490, S. 126 - 130 (2012)

Schweikhard, E. S.; Ziegler, C. M.: Chapter One – Amino Acid Secondary Transporters: Toward a Common Transport Mechanism. Current Topics in Membranes 70, S. 1 - 28 (2012)

Marinelli, F.; Kuhlmann, S.; Grell, E.; Kunte, H.-J.; Ziegler, C.; Faraldo-Gómez, J. D.: Evidence for an allosteric mechanism of substrate release from membrane-transporter accessory binding proteins. Proceedings of the National Academy of Sciences of the United States of America 108 (49), S. E1285 - E1292 (2011)

Gärtner, R. M.; Perez, C.; Koshy, C.; Ziegler, C.: Role of Bundle Helices in a Regulatory Crosstalk in the Trimeric Betaine Transporter BetP. Journal of Molecular Biology 414 (3), S. 327 - 336 (2011)

Ge, L.; Perez, C.; Waclawska, I.; Ziegler, C.; Muller, D. J.: Locating an extracellular K⁺-dependent interaction site that modulates betaine-binding of the Na⁺-coupled betaine symporter BetP. Proceedings of the National Academy of Sciences of the United States of America 108 (43), S. E890 - E898 (2011)

Perez, C.; Khafizov, K.; Forrest, L. R.; Krämer, R.; Ziegler, C.: The role of trimerization in the osmoregulated betaine transporter BetP. EMBO Reports 12 (8), S. 804 - 810 (2011)

Perez, C.; Koshy, C.; Ressl, S.; Nicklisch, S.; Krämer, R.; Ziegler, C.: Substrate specificity and ion coupling in the Na⁺/betaine symporter BetP. EMBO Journal 30, S. 1221 - 1229 (2011)

Tsai, C.-J.; Khafizov, K.; Hakulinen, J.; Forrest, L. R.; Krämer, R.; Kühlbrandt, W.; Ziegler, C.: Structural Asymmetry in a Trimeric Na⁺/Betaine Symporter, BetP, from Corynebacterium glutamicum. Journal of Molecular Biology 407 (3), S. 368 - 381 (2011)

Forrest, L. R.; Krämer, R.; Ziegler, C.: The structural basis of secondary active transport mechanisms. Biochimica et Biophysica Acta, Bioenergetics 1807 (2), S. 167 - 188 (2011)

Ziegler, C.; Bremer, E.; Krämer, R.: The BCCT family of carriers: from physiology to crystal structure. Molecular Microbiology 78 (1), S. 13 - 34 (2010)

Schweikhard, E. S.; Kuhlmann, S. I.; Kunte, H.-J.; Grammann, K.; Ziegler, C. M.: Structure and Function of the Universal Stress Protein TeaD and its Role in Regulating the Ectoine Transporter TeaABC of Halomonas elongata DSM 2581^T. Biochemistry 49 (10), S. 2194 - 2204 (2010)

Krämer, R.; Ziegler, C.: Regulative interactions of the osmosensing C-terminal domain in the trimeric glycine betaine transporter BetP from Corynebacterium glutamicum. Biological Chemistry 390 (8), S. 685 - 691 (2009)

Appel, M.; Hizlan, D.; Vinothkumar, K. R.; Ziegler, C.; Kühlbrandt, W.: Conformations of NhaA, the Na⁺/H⁺ Exchanger from Escherichia coli, in the pH-Activated and Ion-Translocating States. Journal of Molecular Biology 388 (3), S. 659 - 672 (2009)

Ressl, S.; Terwisscha van Scheltinga, A. C.; Vonrhein, C.; Ott, V.; Ziegler, C.: Molecular basis of transport and regulation in the Na⁺/betaine symporter BetP. Nature 458 (7234), S. 47 - 52 (2009)

Kuhlmann, S. I.; Terwisscha van Scheltinga, A. C.; Bienert, R.; Kunte, H.-J.; Ziegler, C.: 1.55 Å Structure of the Ectoine Binding Protein TeaA of the Osmoregulated TRAP-Transporter TeaABC from Halomonas elongata. Biochemistry 47 (36), S. 9475 - 9485 (2008)

Tsai, C.-J.; Ejsing, C. S.; Shevchenko, A.; Ziegler, C.: The role of lipids and salts in two-dimensional crystallization of the glycine–betaine transporter BetP from Corynebacterium glutamicum. Journal of Structural Biology 160 (3), S. 275 - 286 (2007)

Kedrov, A.; Ziegler, C.; Muller, D. J.: Differentiating Ligand and Inhibitor Interactions of a Single Antiporter. Journal of Molecular Biology 362 (5), S. 925 - 932 (2006)

Kedrov, A.; Janovjak, H.; Ziegler, C.; Kuhlbrandt, W.; Muller, D. J.: Observing Folding Pathways and Kinetics of a Single Sodium-proton Antiporter from Escherichia coli. Journal of Molecular Biology 355, S. 2 - 8 (2006)

Kedrov, A.; Krieg, M.; Ziegler, C.; Kühlbrandt, W.; Muller, D.: Locating ligand binding and activation of a single antiporter. EMBO Reports 6 (7), S. 668 - 674 (2005)

Tsai, C.-J.; Ziegler, C.: Structure Determination of Secondary Transport Proteins by Electron Crystallography: Two-Dimensional Crystallization of the Betaine Uptake System BetP. Journal of Molecular Microbiology and Biotechnology 10 (2-4), S. 197 - 207 (2005)

Kedrov, A.; Ziegler, C.; Janovjak, H.; Kühlbrandt, W.; Müller, D. J.: Controlled Unfolding and Refolding of a Single Sodium-proton Antiporter using Atomic Force Microscopy. Journal of Molecular Biology (London) 340 (5), S. 1143 - 1152 (2004)

Ziegler, C.; Morbach, S.; Schiller, D.; Krämer, R.; Tziatzios, R.; Schubert, D.; Kühlbrandt, W.: Projection Structure and Oligomeric State of the Osmoregulated Sodium/Glycine Betaine Symporter BetP of Corynebacterium glutamicum. Journal of Molecular Biology 337 (5), S. 1137 - 1147 (2004)

Khafizov, K.; Perez, C.; Tsai, C.-J.; Ziegler, C.; Forrest, L. R.: Computational and Experimental Studies of Substrate Binding, Conformational Change and Importance of the Trimeric State in the Glycine Betaine Transporter BetP. Biophysical Journal (Annual Meeting Abstracts) 100 (3, Supplement 1), S. 132a - 132a (2011)