Max Planck Institute of Biophysics

Publications of Deryck J. Mills

All genres

Journal Article (45)

2022

Journal Article

Lee, Y.; Wiriyasermkul, P.; Kongpracha, P.; Moriyama, S.; Mills, D. J.; Kühlbrandt, W.; Nagamori, S.: Ca²⁺-mediated higher-order assembly of heterodimers in amino acid transport system b^0,+ biogenesis and cystinuria. Nature Communications 13, 2708 (2022)

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2021

Journal Article

Parey, K.; Lasham, J.; Mills, D. J.; Djurabekova, A.; Haapanen, O.; Yoga, E. G.; Xie, H.; Kühlbrandt, W.; Sharma, V.; Vonck, J. et al.; Zickermann, V.: High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Science Advances 7 (46), eabj3221 (2021)

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Journal Article

Heit, S.; Geurts, M. M. G.; Murphy, B. J.; Corey, R. A.; Mills, D. J.; Kühlbrandt, W.; Bublitz, M.: Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state. Science Advances 7 (46), eabj5255 (2021)

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Journal Article

Wieferig, J.-P.; Mills, D. J.; Kühlbrandt, W.: Devitrification reduces beam-induced movement in cryo-EM. IUCrJ 8 (Pt 2), pp. 186 - 194 (2021)

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Journal Article

Cunha, E. S.; Chen, X.; Sanz-Gaitero, M.; Mills, D. J.; Luecke, H.: Cryo-EM structure of Helicobacter pylori urease with an inhibitor in the active site at 2.0 Å resolution. Nature Communications 12 (1), 230 (2021)

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Journal Article

Mills, D. J.: Setting up and operating a cryo-EM laboratory. Quarterly Reviews of Biophysics 54, e2 (2021)

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2020

Journal Article

Ebenhoch, R.; Prinz, S.; Kaltwasser, S.; Mills, D. J.; Meinecke, R.; Rübbelke, M.; Reinert, D.; Bauer, M.; Weixler, L.; Zeeb, M. et al.; Vonck, J.; Nar, H.: A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America 117 (50), pp. 31838 - 31849 (2020)

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Journal Article

Wu, D.; Grund, T. N.; Welsch, S.; Mills, D.; Michel, M.; Safarian, S.; Michel, H.: Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America 117 (35), 202008111, pp. 21281 - 21287 (2020)

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Journal Article

Tascón, I.; Sousa, J. S.; Corey, R. A.; Mills, D. J.; Griwatz, D.; Aumüller, N.; Mikusevic, V.; Stansfeld, P. J.; Vonck, J.; Hänelt, I.: Structural basis of proton-coupled potassium transport in the KUP family. Nature Communications 11, 626 (2020)

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2019

Journal Article

Brünle, S.; Eisinger, M. L.; Poppe, J.; Mills, D. J.; Langer, J. D.; Vonck, J.; Ermler, U.: Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism. Proceedings of the National Academy of Sciences of the United States of America 52 (116), pp. 26497 - 26504 (2019)

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Journal Article

Parey, K.; Haapanen, O.; Sharma, V.; Köfeler, H.; Züllig, T.; Prinz, S.; Siegmund, K.; Wittig, I.; Mills, D.; Vonck, J. et al.; Kühlbrandt, W.; Zickermann, V.: High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease. Science Advances 5 (12), p. eaax9484 (2019)

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Journal Article

Pfeil-Gardiner, O.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.: A comparative study of single-particle cryo-EM with liquid-nitrogen and liquid-helium cooling. IUCrJ 6, pp. 1099 - 1105 (2019)

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Journal Article

Safarian, S.; Hahn, A.; Mills, D.; Radloff, M.; Eisinger, M. L.; Nikolaev, A.; Meier-Credo, J.; Melin, F.; Miyoshi, H.; Gennis, R.B. et al.; Sakamoto, J.; Langer, J. D.; Hellwig, P.; Kühlbrandt, W.; Michel, H.: Active site rearrangement and structural divergence in prokaryotic respiratory oxidases. Science 366 (6461), pp. 100 - 104 (2019)

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Journal Article

Murphy, B. J.; Klusch, N.; Langer, J. D.; Mills, D.; Yildiz, Ö.; Kühlbrandt, W.: Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F₁-F_o coupling. Science 364 (6446), eaaw9128, p. 1155 (2019)

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2018

Journal Article

Parey, K.; Brandt, U.; Xie, H.; Mills, D. J.; Siegmund, K.; Vonck, J.; Kühlbrandt, W.; Zickermann, V.: Cryo-EM structure of respiratory complex I at work. eLife 7, e39213 (2018)

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Journal Article

Sousa, J. S.; Calisto, F.; Langer, J. D.; Mills, D. J.; Refojo, P. N.; Teixeira, M.; Kühlbrandt, W.; Vonck, J.; Pereira, M. M.: Structural basis for energy transduction by respiratory alternative complex III. Nature Communications 9, 1728 (2018)

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Journal Article

Hahn, A.; Vonck, J.; Mills, D. J.; Meier, T.; Kühlbrandt, W.: Structure, mechanism, and regulation of the chloroplast ATP synthase. Science 360 (6389), pp. 1 - 10 (2018)

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2017

Journal Article

Klusch, N.; Murphy, B. J.; Mills, D.; Yildiy, Ö.; Kühlbrandt, W.: Structural basis of proton translocation and force generation in mitochondrial ATP synthase. eLife 6, e33274 (2017)

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Journal Article

Bausewein, T.; Mills, D. J.; Langer, J. D.; Nitschke, B.; Nussberger, S.; Kühlbrandt, W.: Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell 170 (4), pp. 693 - 700 (2017)

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Journal Article

van Pee, K.; Neuhaus, A.; D'Imprima, E.; Mills, D. J.; Kühlbrandt, W.; Yildiz, Ö.: CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin. eLife 6, e23644 (2017)

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Journal Article

Diskowski, M.; Mehdipour, A. R.; Wunnicke, D.; Mills, D. J.; Mikusevic, V.; Bärland, N.; Hoffmann, J.; Morgner, N.; Steinhoff, H.-J.; Hummer, G.: Helical jackknives control the gates of the double-pore K⁺ uptake system KtrABs. eLife, pp. 1 - 21 (2017)

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Journal Article

Kohler, R.; Mooney, R. A.; Mills, D. J.; Landick, R.; Cramer, P.: Architecture of a transcribing-translating expressome. Science 356, pp. 194 - 197 (2017)

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Journal Article

López-Alonso, J. P.; Kaminishi, T.; Kikuchi, T.; Hirata, Y.; Iturrioz, I.; Dhimole, N.; Schedlbauer, A.; Hase, Y.; Goto, S.; Kurita, D. et al.; Muto, A.; Zhou, S.; Naoe, C.; Mills, D. J.; Gil-Carton, D.; Takemoto, C.; Himeno, H.; Fucini, P.; Connell, S. R.: RsgA couples the maturation state of the 30S ribosomal decoding center to activation of its GTPase pocket. Nucleic Acids Research 45 (11), pp. 6945 - 6959 (2017)

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Journal Article

Schulz, S.; Wilkes, M.; Mills, D. J.; Kühlbrandt, W.; Meier, T.: Molecular architecture of the N‐type ATPase rotor ring from Burkholderia pseudomallei. EMBO Reports 18 (6), pp. 1 - 10 (2017)

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Journal Article

Vonck, J.; Mills, D. J.: Advances in high-resolution cryo-EM of oligomeric enzymes. Current Opinion in Structural Biology 46, pp. 48 - 54 (2017)

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2016

Journal Article

Sousa, J. S.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.: Functional asymmetry and electron flow in the bovine respirasome. eLife 5, e21290 (2016)

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Journal Article

Vonck, J.; Parcej, D. N.; Mills, D. J.: Structure of Alcohol Oxidase from Pichia pastoris by Cryo-Electron Microscopy. PLOS ONE 11 (7), e0159476 (2016)

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Journal Article

Chaudhury, P.; Neiner, T.; D'Imprima, E.; Banerjee, A.; Reindl, S.; Ghosh, A.; Arvai, A. S.; Mills, D. J.; van der Does, C.; Tainer, J. A. et al.; Vonck, J.; Albers, S.: The nucleotide-dependent interaction of FlaH and FlaI isessential for assembly and function of the archaellum motor. Molecular Microbiology 99 (4), pp. 674 - 685 (2016)

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Journal Article

D'Imprima, E.; Mills, D. J.; Parey, K.; Brandt, U.; Kühlbrandt, W.; Zickermann, V.; Vonck, J.: Cryo-EM structure of respiratory complex I reveals a link to mitochondrial sulfur metabolism. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1857 (12), pp. 1935 - 1942 (2016)

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Journal Article

Hahn, A.; Parey, K.; Bublitz, M.; Mills, D. J.; Zickermann, V.; Vonck, J.; Kühlbrandt, W.; Meier, T.: Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology. Molecular Cell 63, pp. 1 - 12 (2016)

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2015

Journal Article

Allegretti, M.; Klusch, N.; Mills, D. J.; Vonck, J.; Kühlbrandt, W.; Davies, K. M.: Horizontal membrane-intrinsic α-helices in the stator a-subunit of an F-type ATP synthase. Nature 521, pp. 237 - 240 (2015)

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Journal Article

Jiko, C.; Davies, K. M.; Shinzawa-Itoh, K.; Tani, K.; Maeda, S.; Mills, D. J.; Tsukihara, T.; Fujiyoshi, Y.; Kühlbrandt, W.; Gerle, C.: Bovine F₁F₀ ATP synthase monomers bend the lipid bilayer in 2D membrane crystals. eLife 4, e06119 (2015)

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Journal Article

Fischer, M.; Rhinow, D.; Zhu, Z.; Mills, D. J.; Zhao, Z. K.; Vonck, J.; Grininger, M.: Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS. Protein Science 24 (6), pp. 987 - 995 (2015)

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2014

Journal Article

Allegretti, M.; Mills, D. J.; McMullen, G.; Kühlbrandt, W.; Vonck, J.: Atomic model of the F₄₂₀-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector. eLife 3, e01963 (2014)

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Journal Article

Daum, B.; Quax, T. E. F.; Sachse, M.; Mills, D. J.; Reimann, J.; Yildiz, Ö.; Häder, S.; Saveanu, C.; Forterre, P.; Albers, S.-V. et al.; Kühlbrandt, W.; Prangishvili, D.: Self-assembly of the general membrane-remodeling protein PVAP into sevenfold virus-associated pyramids. Proceedings of the National Academy of Sciences of the United States of America 111 (10), pp. 3829 - 3834 (2014)

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Journal Article

Davies, K. M.; Daum, B.; Gold, V. A. M.; Mühleip, A. W.; Brandt, T.; Blum, T.; Mills, D. J.; Kühlbrandt, W.: Visualization of ATP Synthase Dimers in Mitochondria by Electron Cryo-tomography. Journal of Visualized Experiments (91 doi: 10.3791/51228), e51228 (2014)

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2013

Journal Article

Mills, D. J.; Vitt, S.; Strauss, M.; Shima, S.; Vonck, J.: De novo modeling of the F₄₂₀-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. eLife 2, e00218 (2013)

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Journal Article

Ciccarelli, L.; Connell, S. R.; Enderle, M.; Mills, D. J.; Vonck, J.; Grininger, M.: Structure and Conformational Variability of the Mycobacterium tuberculosis Fatty Acid Synthase Multienzyme Complex. Structure 21 (7), pp. 1251 - 1257 (2013)

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2012

Journal Article

Banerjee, A.; Ghosh, A.; Mills, D. J.; Kahnt, J.; Vonck, J.; Albers, S.-V.: FlaX, A Unique Component of the Crenarchaeal Archaellum, Forms Oligomeric Ring-shaped Structures and Interacts with the Motor ATPase FlaI. The Journal of Biological Chemistry 287 (52), pp. 43322 - 43330 (2012)

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Journal Article

Hizlan, D.; Robson, A.; Whitehouse, S.; Gold, V. A.; Vonck, J.; Mills, D.; Kühlbrandt, W.; Collinson, I.: Structure of the SecY Complex Unlocked by a Preprotein Mimic. Cell Reports 1 (1), pp. 21 - 28 (2012)

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2011

Journal Article

Althoff, T.; Mills, D. J.; Popot, J.-L.; Kühlbrandt, W.: Arrangement of electron transport chain components in bovine mitochondrial supercomplex I₁III₂IV₁. EMBO Journal 30, pp. 4652 - 4664 (2011)

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2010

Journal Article

Gipson, P.; Mills, D. J.; Wouts, R.; Grininger, M.; Vonck, J.; Kühlbrandt, W.: Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy. Proceedings of the National Academy of Sciences of the United States of America 107 (20), pp. 9164 - 9169 (2010)

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2009

Journal Article

Kamal, M. M.; Mills, D.; Grzybeck, M.; Howard, J.: Measurement of the membrane curvature preference of phospholipids reveals only weak coupling between lipid shape and leaflet curvature. Proceedings of the National Academy of Sciences of the United States of America 106 (52), pp. 22245 - 22250 (2009)

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2004

Journal Article

Schmidt-Krey, I.; Kanaoka, Y.; Mills, D. J.; Lam, B. K.; Irikura, D.; Haase, W.; Austen, K. F.; Kühlbrandt, W.: Human Leukotriene C₄ Synthase at 4.5 Å Resolution in Projection. Structure 12, pp. 2009 - 2014 (2004)

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2001

Journal Article

Behlau, M.; Mills, D. J.; Quader, H.; Kühlbrandt, W.; Vonck, J.: Projection structure of the monomeric porin OmpG at 6 å resolution. Journal of Molecular Biology (London) 305 (1), pp. 71 - 77 (2001)

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Book Chapter (1)

2013

Book Chapter

Mills, D. J.; Vonck, J.: Choice and Maintenance of Equipment for Electron Crystallography. In: Electron Crystallography of Soluble and Membrane Proteins: Methods and Protocols, Vol. 995, pp. 331 - 351 (Eds. Schmidt-Krey, I.; Cheng, Y.). Springer Science+Business Media New York 2013, Humana Totowa, NJ (2013)

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Proceedings (2)

2018

Proceedings

Cryo-EM structure of the alternative complex III from Rhodothermus marinus (Biochim. Biophys. Acta (BBA) - Bioenergetics, 1859). (2018), 1 p.

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Proceedings

The cryo EM structure of respiratory complex I from Yarrowia lipolytica (Biochim. Biophys. Acta (BBA) - Bioenergetics, 1859). Budapest, Hungary (2018), 01 p.

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