Max Planck Institute of Biophysics

Hartmut Michel: Molecular Membrane Biology – Department Publications

Journal Article (616)

2024

Journal Article

Joshi, T.; Demmer, U.; Schneider, C.; Glaser, T.; Warkentin, E.; Ermler, U.; Mack, M.: The phosphatase RosC from Streptomyces davaonensis is used for roseoflavin biosynthesis and has evolved to largely prevent dephosphorylation of the important cofactor riboflavin-5'-phosphate. Journal of Molecular Biology 436 (20), 168734 (2024)

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Ri, K.; Weng, T.-H.; Claveras Cabezudo, A.; Jösting, W.; Zhang, Y.; Bazzone, A.; Leong, N. C. P.; Welsch, S.; Doty, R. T.; Gursu, G. et al.; Lim, T. J. Y.; Schmidt, S. L.; Abkowitz, J. L.; Hummer, G.; Wu, D.; Nguyen, L. N.; Safarian, S.: Molecular mechanism of choline and ethanolamine transport in humans. Nature 630, pp. 501 - 508 (2024)

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Gehl, M.; Demmer, U.; Ermler, U.; Shima, S.: Mutational and structural studies of (βα)₈-barrel fold methylene-tetrahydropterin reductases utilizing a common catalytic mechanism. Protein Science 33 (6), e5018 (2024)

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Lyratzakis, A.; Daskalakis, V.; Xie, H.; Tsiotis, G.: The synergy between the PscC subunits for electron transfer to the P₈₄₀ special pair in Chlorobaculum tepidum. Photosynthesis Research 160 (2-3), pp. 87 - 96 (2024)

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Aziz, I.; Kayastha, K.; Kaltwasser, S.; Vonck, J.; Welsch, S.; Murphy, B. J.; Kahnt, J.; Wu, D.; Wagner, T.; Shima, S. et al.; Ermler, U.: Structural and mechanistic basis of the central energy-converting methyltransferase complex of methanogenesis. PNAS 121 (14), e2315568121 (2024)

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2023

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Demmer, U.; Lemaire, O.; Belhamri, M.; Ermler, U.: Ethoxylate Polymer-Based 96-Well Screen for Protein Crystallization. Crystals 13, 1519 (2023)

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Gehl, M.; Demmer, U.; Ermler, U.; Shima, S.: Crystal structure of FAD-independent methylene-tetrahydrofolate reductase from Mycobacterium hassiacum. Proteins: Structure, Function, and Bioinformatics 91 (9), pp. 1329 - 1340 (2023)

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Meier-Credo, J.; Heiniger, B.; Schori, C.; Rupprecht, F.; Michel, H.; Ahrens, C. A.; Langer, J. D.: Detection of Known and Novel Small Proteins in Pseudomonas stutzeri Using a Combination of Bottom-Up and Digest-Free Proteomics and Proteogenomics. Analytical Chemistry 95, pp. 11892 - 11900 (2023)

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Wu, D.; Mehdipour, A. R.; Finke, F.; Goojani, H. G.; Groh, R. R.; Grund, T. N.; Reichhart, T. M. B.; Zimmermann, R.; Welsch, S.; Bald, D. et al.; Shepherd, M.; Hummer, G.; Safarian, S.: Dissecting the conformational complexity and mechanism of a bacterial heme transporter. Nature Chemical Biology 19 (8), pp. 992 - 1003 (2023)

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Thielmann, Y.; Luft, T.; Zint, N.; Koepke, J.: Crystal search - feasibility study of a real-time deep learning process for crystallization well images. Acta Crystallographica Section A: Foundations and Advances A79 (Part 4), pp. 331 - 338 (2023)

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Drakonaki, A.; Mathioudaki, E.; Geladas, E. D.; Konsolaki, E.; Vitsaxakis, N.; Chaniotakis, N.; Xie, H.; Tsiotis, G.: Production of Polyhydroxybutyrate by Genetically Modified Pseudomonas sp. phDV1: A Comparative Study of Utilizing Wine Industry Waste as a Carbon Source. Microorganisms 11 (16), 1592 (2023)

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Kalavacherla, T.; Buschmann, S.; Schleker, E. S. M.; Michel, H.; Reinhart, C.: Purification and characterization of eukaryotic ATP-dependent transporters homologously expressed in Pichia pastoris for structural studies by cryo-electron microscopy. Protein Expression and Purification 204, 106230 (2023)

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Hegemann, P.; Michel, H.: Dieter Oesterhelt (1940-2022): Life with light and color, pioneer of membrane protein research. Biophysics and Physicobiology 20 (Supplemental), e201010 (2023)

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Hegemann, P.; Michel, H.: Dieter Oesterhelt (1940–2022). Science 379 (6630), p. 337 (2023)

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Xie, H.; Lyratzakis, A.; Khera, R.; Koutantou, M.; Welsch, S.; Michel, H.; Tsiotis, G.: Cryo-EM structure of the whole photosynthetic reaction center apparatus from the green sulfur bacterium Chlorobaculum tepidum. Proceedings of the National Academy of Sciences of the United States of America 120 (5), e2216734120 (2023)

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Grund, T. N.; Kabashima, Y.; Kusumoto, T.; Wu, D.; Welsch, S.; Sakamoto, J.; Michel, H.; Safarian, S.: The cryoEM structure of cytochrome bd from C. glutamicum provides novel insights into structural properties of actinobacterial terminal oxidases. Frontiers in Chemistry (2023)

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2022

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Vitt, S.; Prinz, S.; Eisinger, M. L.; Ermler, U.; Buckel, W.: Purification and structural characterization of the Na⁺-translocating ferredoxin: NAD⁺ reductase (Rnf) complex of Clostridium tetanomorphum. Nature Communications 13, 6315 (2022)

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Schleker, E. S. M.; Buschmann, S.; Xie, H.; Welsch, S.; Michel, H.; Reinhart, C.: Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules. Proceedings of the National Academy of Sciences of the United States of America 126 (43), pp. 8646 - 8654 (2022)

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Mathioudaki, E.; Alifragis, Y.; Fouskaki, M.; Chochlakis, D.; Xie, H.; Psaroulaki, A.; Tsiotis, G.; Chaniotakis, N.: Electrochemical Antigenic Sensor for the Diagnosis of Chronic Q Fever. Current Research in Biotechnology 4, pp. 537 - 543 (2022)

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Zöller, J.; Hong, S.; Eisinger, M. L.; Anderson, M.; Radloff, M.; Desch, K.; Gennis, R.; Langer, J. D.: Ligand binding and conformational dynamics of the E. coli nicotinamide nucleotide transhydrogenase revealed by hydrogen/deuterium exchange mass spectrometry. Computational and Structural Biotechnology Journal 20, pp. 5430 - 5439 (2022)

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Khera, R.; Mehdipour, A. R.; Bolla, J. R.; Kahnt, J.; Welsch, S.; Ermler, U.; Münke, C.; Robinson, C. V.; Hummer, G.; Xie, H. et al.; Michel, H.: Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism. The EMBO Journal 41 (18), e109990 (2022)

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Meier-Credo, J.; Preiss, L.; Wüllenweber, I.; Resemann, A.; Nordmann, C.; Zabret, J.; Suckau, D.; Michel, H.; Nowacyk, M. M.; Meier, T. et al.; Langer, J. D.: Top-Down Identification and Sequence Analysis of Small Membrane Proteins Using MALDI-MS/MS. Journal of the American Society for Mass Spectrometry 33 (7), pp. 1293 - 1302 (2022)

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Kayastha, K.; Katsyv, A.; Himmrich, C.; Welsch, S.; Schuller, J. M.; Ermler, U.; Müller, V.: Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex. eLife 11, e77095 (2022)

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Aziz, I.; Kaltwasser, S.; Kayastha, K.; Khera, R.; Vonck, J.; Ermler, U.: The molybdenum storage protein forms and deposits distinct polynuclear tungsten oxygen aggregates. Journal of Inorganic Biochemistry 234, 111904 (2022)

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Zhao, J.; Hellwig, N.; Djahanschiri, B.; Khera, R.; Morgner, N.; Ebersberger, I.; Wang, J.; Michel, H.: Assembly and Functional Role of PACE Transporter PA2880 from Pseudomonas aeruginosa. Microbiology Spectrum 10 (2), e01453-21 (2022)

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Weidenweber, S.; Schühle, K.; Lippert, M.-L.; Mock, J.; Seubert, A.; Demmer, U.; Ermler, U.; Heider, J.: Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyses the final step of anaerobic toluene metabolism. The FEBS Journal 5, 166 (2022)

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Hards, K.; Cheung, C.-Y.; Waller, N.; Adolph, C.; Keighley, L.; Tee, Z. S.; Harold, L. K.; Menorca, A.; Bujaroski, R. S.; Buckley, B. J. et al.; Tyndall, J. D.A.; McNeil, M. B.; Rhee, K. Y.; Opel-Reading, H. K.; Krause, K.; Preiss, L.; Langer, J. D.; Meier, T.; Hasenoehrl, E. J.; Berney, M.; Kelso, M. J.; Cook, G. M.: An amiloride derivative is active against the F₁F_o-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology 5 (1), 166 (2022)

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2021

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Grund, T. N.; Radloff, M.; Wu, D.; Goojani, H. G.; Witte, L. F.; Jösting, W.; Buschmann, S.; Müller, H.; Elamri, I.; Welsch, S. et al.; Schwalbe, H.; Michel, H.; Bald, D.; Safarian, S.: Mechanistic and structural diversity between cytochrome bd isoforms of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 118 (50), e2114013118 (2021)

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Konia, E.; Chatzicharalampous, K.; Drakonaki, A.; Münke, C.; Ermler, U.; Tsiotis, G.; Pavlidis, I. V.: Rational engineering of Luminiphilus syltensis ( R)-selective amine transaminase for the acceptance of bulky substrates. Chemical Communications 57 (96), pp. 12948 - 12951 (2021)

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Radloff, M.; Elamri, I.; Grund, T. N.; Witte, L. F.; Hohmann, K. F.; Nakagaki, S.; Goojani , H. G.; Nasiri, H.; Miyoshi , H.; Bald, D. et al.; Xie, H.; Sakamoto, J.; Schwalbe, H.; Safarian, S.: Short-chain aurachin D derivatives are selective inhibitors of E. coli cytochrome bd-I and bd-II oxidases. Scientific Reports 11 (1), e23852 (2021)

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Kolbe, F.; Safarian, S.; Piórek, Ż.; Welsch, S.; Müller, H.; Michel, H.: Cryo-EM structures of intermediates suggest an alternative catalytic reaction cycle for cytochrome c oxidase. Nature Communications 12, 6903 (2021)

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Kung, J.; Meier, A.-K.; Willistein, M.; Weidenweber, S.; Demmer, U.; Ermler, U.; Boll, M.: Structural basis of cyclic 1,3-diene forming acyl-coenzyme A dehydrogenases. Chembiochem 22 (22), pp. 3172 - 3177 (2021)

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Zhao, J.; Xie, H.; Mehdipour, A. R.; Safarian, S.; Ermler, U.; Münke, C.; Thielmann, Y.; Hummer, G.; Ebersberger, I.; Wang, J. et al.; Michel, H.: The structure of the Aquifex aeolicus MATE family multidrug resistance transporter and sequence comparisons suggest the existence of a new subfamily. Proceedings of the National Academy of Sciences of the United States of America 118 (46), e2107335118 (2021)

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Parey, K.; Lasham, J.; Mills, D. J.; Djurabekova, A.; Haapanen, O.; Yoga, E. G.; Xie, H.; Kühlbrandt, W.; Sharma, V.; Vonck, J. et al.; Zickermann, V.: High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. Science Advances 7 (46), eabj3221 (2021)

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Mathioudaki, E.; Arvaniti, K.; Münke, C.; Drakonaki, A.; Vranakis, I.; Koutantou, M.; Psaroulaki, A.; Xie, H.; Tsiotis, G.: Expression, purification and characterization of the IcmG and IcmK proteins of the Type IVB secretion system from Coxiella burnetii. Protein Expression and Purification 186, 105905 (2021)

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Safarian, S.; Opel-Reading, H. K.; Wu, D.; Mehdipour, A. R.; Hards, K.; Harold, L. H.; Radloff, M.; Stewart, I.; Welsch, S.; Hummer, G. et al.; Cook, G. M.; Krause, K. L.; Michel, H.: The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. Nature Communications 12 (1), 5236 (2021)

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Nikolaev, A.; Safarian, S.; Thesseling, A.; Wohlwend, D.; Friedrich, T.; Michel, H.; Kusumoto, T.; Sakamoto, J.; Melin, F.; Hellwig, P.: Electrocatalytic evidence of the diversity of the oxygen reaction in the bacterial bd oxidase from different organisms. Biochimica et Biophysica Acta, Bioenergetics 1862 (8), e148436 (2021)

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Kanavaki, I.; Drakonaki, A.; Geladas, E. D.; Spyros, A.; Xie, H.; Tsiotis, G.: Polyhydroxyalkanoate (PHA) Production in Pseudomonas sp. phDV1 Strain Grown on Phenol as Carbon Sources. Microorganisms 9 (8), 1636 (2021)

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Zhu, G.; Zeng, H.; Zhang, S.; Juli, J.; Tai, L.; Zhang, D.; Pang , X.; Zhang, Y.; Lam, S. M.; Zhu, Y. et al.; Peng, G.; Michel, H.; Sun, F.: The unusual homodimer of a heme‐copper terminal oxidase allows itself to utilize two electron donors. Angewandte Chemie, International Edition in English 60 (24), pp. 13323 - 13330 (2021)

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Kayastha, K.; Vitt, S.; Buckel, W.; Ermler, U.: Flavins in the electron bifurcation process. Archives of Biochemistry and Biophysics 701, 108796 (2021)

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Appel, L.; Willistein, M.; Dahl, C.; Ermler, U.; Boll, M.: Functional diversity of prokaryotic HdrA(BC) modules: Role in flavin-based electron bifurcation processes and beyond. Biochimica et Biophysica Acta, Bioenergetics 1862 (4), 148379 (2021)

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Ernst, C.; Kayastha, K.; Koch , T.; Venceslau, S. S.; Pereira, I. A.C.; Demmer, U.; Ermler, U.; Dahl, C.: Structural and spectroscopic characterization of a HdrA‐like subunit from Hyphomicrobium denitrificans. The FEBS Journal 288 (5), pp. 1664 - 1678 (2021)

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2020

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Psaroulaki, A.; Mathioudaki, E.; Vranakis, I.; Chochlakis, D.; Yachnakis, E.; Kokkini , S.; Xie, H.; Tsiotis, G.: In the Search of Potential Serodiagnostic Proteins to Discriminate Between Acute and Chronic Q Fever in Humans. Some Promising Outcomes. Frontiers in Cellular and Infection Microbiology 10, 557027 (2020)

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Shima, S.; Huang, G.; Wagner, T.; Ermler, U.: Structural Basis of Hydrogenotrophic Methanogenesis. Annual Review of Microbiology 74, pp. 713 - 733 (2020)

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Wu, D.; Grund, T. N.; Welsch, S.; Mills, D.; Michel, M.; Safarian, S.; Michel, H.: Structural basis for amino acid exchange by a human heteromeric amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America 117 (35), 202008111, pp. 21281 - 21287 (2020)

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Elamri, I.; Radloff, M.; Hohmann, K. F.; Nimbarte, V. D.; Nasiri, H. R.; Bolte, M.; Safarian, S.; Michel, H.; Schwalbe, H.: Synthesis and Biological Screening of new Lawson Derivatives as selective substrate‐based Inhibitors of Cytochrome bo₃ Ubiquinol Oxidase from Escherichia coli. ChemMedChem 15 (14), pp. 1262 - 1271 (2020)

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Zeng, H.; Zhu, G.; Zhang, S.; Li, X.; Martin, J.; Morgner, N.; Sun, F.; Peng, G.; Xie, H.; Michel, H.: Isolated Heme A Synthase from Aquifex aeolicus Is a Trimer. mBio 11 (3), e02615-19 (2020)

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Neuhaus, A.; Selvaraj, M.; Salzer, R.; Langer, J. D.; Kruse, K.; Kirchner, L.; Sanders, K.; Daum, B.; Averhoff, B.; Gold, V.: Cryo-electron microscopy reveals two distinct type IV pili assembled by the same bacterium. Nature Communications 11, 2231 (2020)

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Vitt, S.; Prinz, S.; Hellwig, N.; Morgner, N.; Ermler, U.; Buckel, W.: Molecular and Low-Resolution Structural Characterization of the Na+-Translocating Glutaconyl-CoA Decarboxylase From Clostridium symbiosum. Frontiers in Microbiology 11, 480 (2020)

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Huang, G.; Wagner, T.; Demmer, U.; Warkentin, E.; Ermler, U.; Shima, S.: The Hydride Transfer Process in NADP-dependent Methylene-tetrahydromethanopterin Dehydrogenase. Journal of Molecular Biology (London) 432 (7), pp. 2042 - 2054 (2020)

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Huang, G.; Wagner, T.; Ermler, U.; Shima, S.: Methanogenesis involves direct hydride transfer from H₂ to an organic substrate. Nature Reviews Chemistry 4 (2), pp. 213 - 221 (2020)

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Zhu, G.; Zeng, H.; Zang, S.; Juli, J.; Pang, X.; Hoffman, J.; Zhang, Y.; Morgner, N.; Zhu, Y.; Peng, G. et al.; Michel, H.; Sun, F.: A 3.3 Å‐Resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of its Thermal Stability. Angewandte Chemie, International Edition in English 59 (1), pp. 343 - 351 (2020)

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2019

Journal Article

Brünle, S.; Eisinger, M. L.; Poppe, J.; Mills, D. J.; Langer, J. D.; Vonck, J.; Ermler, U.: Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism. Proceedings of the National Academy of Sciences of the United States of America 52 (116), pp. 26497 - 26504 (2019)

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Lencina, A. M.; Koepke, J.; Preu, J.; Münke, C.; Gennis, R. B.; Michel, H.; Schurig-Briccio, L. A.: Characterization and X-ray structure of the NADH-dependent coenzyme A disulfide reductase from Thermus thermophilus. Biochimica et Biophysica Acta, Bioenergetics 1860 (11), e148080 (2019)

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Wang, X.; You, X.; Langer, J. D.; Hou, J.; Rupprecht, F.; Vlatkovic, I.; Quedenau, C.; Tushev, G.; Epstein, I.; Schaefke, B. et al.; Sun , W.; Fang, L.; Li, G.; Hu , Y.; Schuman, E. M.; Chen, W.: Full-length transcriptome reconstruction reveals a large diversity of RNA and protein isoforms in rat hippocampus. Nature Communications 10, 5009 (2019)

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Safarian, S.; Hahn, A.; Mills, D.; Radloff, M.; Eisinger, M. L.; Nikolaev, A.; Meier-Credo, J.; Melin, F.; Miyoshi, H.; Gennis, R.B. et al.; Sakamoto, J.; Langer, J. D.; Hellwig, P.; Kühlbrandt, W.; Michel, H.: Active site rearrangement and structural divergence in prokaryotic respiratory oxidases. Science 366 (6461), pp. 100 - 104 (2019)

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Kourpa, K.; Manarolaki, E.; Lyratzakis, A.; Strataki, V.; Rupprecht, F. A.; Langer, J. D.; Tsiotis, G.: Proteome Analysis of Enriched Heterocysts from Two Hydrogenase Mutants from Anabaena sp. PCC 7120. Proteomics 19 (19), 1800332 (2019)

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Murphy, B. J.; Klusch, N.; Langer, J. D.; Mills, D.; Yildiz, Ö.; Kühlbrandt, W.: Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F₁-F_o coupling. Science 364 (6446), eaaw9128, p. 1155 (2019)

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Zakrzewska, S.; Mehdipour, A. R.; Malviya, V. N.; Nonaka, T.; Koepke, J.; Muenke, C.; Hausner, W.; Hummer, G.; Safarian, S.; Michel, H.: Inward-facing conformation of a multidrug resistance MATE family transporter. Proceedings of the National Academy of Sciences of the United States of America 116 (25), pp. 12275 - 12284 (2019)

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Langebeck-Jensen, K.; Shahar, O. D.; Schuman, E. M.; Langer, J. D.; Soojin, R.: Larval Zebrafish Proteome Regulation in Response to an Environmental Challenge. Proteomics 19 (14), 1900028 (2019)

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Huang, G.; Wagner, T.; Wodrich, M. D.; Ataka, K.; Bill, E.; Ermler, U.; Hu, X.; Shima, S.: The atomic-resolution crystal structure of activated [Fe]-hydrogenase. Nature Catalysis 2 (6), pp. 537 - 543 (2019)

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Singh, S.; Akhter, M. S.; Dodt, J.; Volkers, P.; Reuter, A.; Reinhart, C.; Krettler, C.; Oldenburg, J.; Biswas, A.: Identification of Potential Novel Interacting Partners for Coagulation Factor XIII B (FXIII-B) Subunit, a Protein Associated with a Rare Bleeding Disorder. International Journal of Molecular Sciences 20 (11), 2682 (2019)

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Willistein, M.; Bechtel, D. F.; Müller, C. S.; Demmer, U.; Heimann, L.; Kayastha, K.; Schünemann, V.; Pierik, A. J.; Ullmann, G. M.; Ermler, U. et al.; Boll, M.: Low potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactorsLow potential enzymatic hydride transfer via highly cooperative and inversely functionalized flavin cofactors. Nature Communications 10, 2074 (2019)

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Watanabe, T.; Wagner, T.; Huang, G.; Kahnt, J.; Ataka, K.; Ermler, U.; Shima, S.: The Bacterial [Fe]‐Hydrogenase Paralog HmdII Uses Tetrahydrofolate Derivatives as Substrates. Angewandte Chemie International Edition in English 58 (11), pp. 3506 - 3510 (2019)

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Alvarez-Castelao, B.; Schanzenbächer, C. T.; Langer, J. D.; Schuman, E. M.: Cell-type-specific metabolic labeling, detection and identification of nascent proteomes in vivo. Nature Protocols 14 (2), pp. 556 - 575 (2019)

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Liu, X.; Zhao, X.; Na, R.; Li, L.; Warkentin, E.; Witt, J.; Lu, X.; Yu, Y.; Wei, Y.; Peng, G. et al.; Li, Y.; Wang, J.: The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism. Protein and Cell 10 (2), pp. 149 - 153 (2019)

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Richter, M.; Moroniak, S. J.; Michel, H.: Identification of competitive inhibitors of the human taurine transporter TauT in a human kidney cell line. Pharmacological Reports 71 (1), pp. 121 - 127 (2019)

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Xie, H.; Valsamidis, G.; Mathioudaki, E.; Tsiotis, G.: Complete Genome Sequence of Pseudomonas sp. Strain phDV1, an Isolate Capable of Efficient Degradation of Aromatic Hydrocarbons. Microbiology Resource Announcement 8 (2), e01171-18 (2019)

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2018

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Poppe, J.; Brünle, S.; Hail, R.; Wiesemann, K.; Schneider, K.; Ermler, U.: The Molybdenum Storage Protein: A soluble ATP hydrolysis‐dependent molybdate pump. The FEBS Journal 285 (24), pp. 4602 - 4616 (2018)

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Brünle, S.; Poppe, J.; Hail, R.; Demmer, U.; Ermler, U.: The molybdenum storage protein - A bionanolab for creating experimentally alterable polyoxomolybdate clusters. Journal of Inorganic Biochemistry 189 (12), pp. 172 - 179 (2018)

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Liu, W.; Liu, A.; Gao, H.; Wang, Q.; Wang, L.; Warkentin, E.; Rao, Z.; Michel, H.; Peng, G.: Structural properties of the peroxiredoxin AhpC2 from the hyperthermophilic eubacterium Aquifex aeolicus. Biochimica et Biophysica Acta (BBA) - General Subjects 1862 (12), pp. 2797 - 2805 (2018)

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Wagner , T.; Huang, G.; Ermler, U.; Shima, S.: How [Fe]-Hydrogenase from Methanothermobacter is Protected Against Light and Oxidative Stress. Angewandte Chemie International Edition in English 57 (46), pp. 15056 - 15059 (2018)

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Reiter, S.; Hülsdunk, P.; Woo, T.; Eberle, J. S.; Akay, L. A.; Longo, A.; Meier-Credo, J.; Kretschmer, F.; Langer, J. D.; Kaschube, M. et al.; Laurent, G.: Elucidating the control and development of skin patterning in cuttlefish. Nature 562 (7727), pp. 361 - 366 (2018)

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Parey, K.; Brandt, U.; Xie, H.; Mills, D. J.; Siegmund, K.; Vonck, J.; Kühlbrandt, W.; Zickermann, V.: Cryo-EM structure of respiratory complex I at work. eLife 7, e39213 (2018)

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Birch, J.; Axford, D.; Foadi, J.; Meyer, A.; Eckhardt, A.; Thielmann, Y.; Moraes, I.: The fine art of integral membrane protein crystallization. Methods 147, pp. 150 - 162 (2018)

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Dörrbaum, A. R.; Kochen, L.; Langer, J. D.; Schuman, E. M.: Local and global influences on protein turnover in neurons and glia. eLife 7, e34202 (2018)

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Peng, G.; Meyer, B.; Sokolova, L.; Liu, W.; Bornemann, S.; Juli, J.; Zwicker, K.; Karas, M.; Brutschy, B.; Michel, H.: Identification and characterization two isoforms of NADH:ubiquinone oxidoreductase from the hyperthermophilic eubacterium Aquifex aeolicus. Biochimica et Biophysica Acta, Bioenergetics 1859 (5), pp. 366 - 373 (2018)

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Sousa, J. S.; Calisto, F.; Langer, J. D.; Mills, D. J.; Refojo, P. N.; Teixeira, M.; Kühlbrandt, W.; Vonck, J.; Pereira, M. M.: Structural basis for energy transduction by respiratory alternative complex III. Nature Communications 9, 1728 (2018)

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Eisinger, M. L.; Nie, L.; Dörrbaum, A. R.; Langer, J. D.; Michel, H.: The Xenobiotic Extrusion Mechanism of the MATE Transporter NorM_PS from Pseudomonas stutzeri. Journal of Molecular Biology (London) 430 (9), pp. 1311 - 1323 (2018)

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Huang, G.; Wagner, T.; Ermler, U.; Bill, E.; Ataka, K.; Shima, S.: Dioxygen Sensitivity of [Fe]‐Hydrogenase in the Presence of Reducing Substrates. Angewandte Chemie International Edition in English 57 (18), pp. 4917 - 4920 (2018)

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Groß, A. S.; Schulz, C.; Kolb, J.; Koster, J.; Wehner, S.; Czaplinski, S.; Khilan, A.; Rohrer, H.; Harter, P. N.; Klingebiel, T. et al.; Langer, J. D.; Geerts, D.: Tumorigenic and Antiproliferative Properties of the TALE-Transcription Factors MEIS2D and MEIS2A in Neuroblastoma. Cancer research: an official organ of the American Association for Cancer Research 78 (8), pp. 1935 - 1947 (2018)

MPG.PuRe

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Joedicke, L.; Mao, J.; Kuenze, G.; Reinhart, C.; Kalavacherla, T.; Jonker, H. R.A.; Richter, C.; Schwalbe, H.; Meiler, J.; Preu, J. et al.; Michel, H.; Glaubitz, C.: The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors. Nature Chemical Biology 13 (3), pp. 284 - 290 (2018)

MPG.PuRe

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Schanzenbächer, C. T.; Langer, J. D.; Schuman, E. M.: Time- and polarity-dependent proteomic changes associated with homeostatic scaling at central synapses. eLife 7, e33322 (2018)

MPG.PuRe

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Demmer, J. K.; Bertsch, J.; Öppinger, C.; Wohlers, H.; Kayastha, K.; Demmer, U.; Ermler, U.; Müller, V.: Molecular basis of the flavin‐based electron‐bifurcating caffeyl‐CoA reductase reaction. FEBS Letters 592 (3), pp. 332 - 342 (2018)

MPG.PuRe

2017

Journal Article

Alvarez-Castelao, B.; Schanzenbächer, C. T.; Hanus, C.; Glock, C.; tom Dieck, S.; Dörrbaum, A. R.; Bartnik, I.; Nassim-Assir, B.; Ciirdaeva, E.; Mueller , A. et al.; Dietrich, D. C.; Tirrell, D. A.; Langer, J. D.; Schuman, E. M.: Cell-type-specific metabolic labeling of nascent proteomes in vivo. Nature Biotechnology 35 (12), pp. 1196 - 1201 (2017)

MPG.PuRe

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Quirnheim Pais, D.; Rathmann, B.; Koepke, J.; Tomova, C.; Wurzinger, P.; Thielmann, Y.: A standardized technique for high-pressure cooling of protein crystals. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) 73 (12), pp. 997 - 1006 (2017)

MPG.PuRe

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Jiang, S.; Wang, L.; Huang, M.; Jia, Z.; Weinert, T.; Warkentin, E.; Liu, C.; Song, X.; Zhang, H.; Witt, J. et al.; Qiu, L.; Peng, G.; Song, L.: DM9 Domain Containing Protein Functions As a Pattern Recognition Receptor with Broad Microbial Recognition Spectrum. Frontiers in immunology 8, 1607 (2017)

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Demmer, J. K.; Chowdhury, N. P.; Selmer, T.; Ermler, U.; Buckel, W.: The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile. Nature Communications 8, 1577 (2017)

MPG.PuRe

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Warkentin, E.; Weidenweber, S.; Schühle, K.; Demmer, U.; Heider, J.; Ermler, U.: A rare polyglycine type II-like helix motif in naturally occurring proteins. Proteins: Structure, Function, and Bioinformatics 85 (11), pp. 2017 - 2023 (2017)

MPG.PuRe

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Eisinger, M. L.; Dörrbaum, A. R.; Michel, H.; Padan, E.; Langer, J. D.: Ligand-induced conformational dynamics of the Escherichia coli Na⁺/H⁺ antiporter NhaA revealed by hydrogen/deuterium exchange mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 114 (44), pp. 11691 - 11696 (2017)

MPG.PuRe

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Sommer, M.; Xie, H.; Michel, H.: Pseudomonas stutzeri as an alternative host for membrane proteins. Microbial Cell Factories 16, 157 (2017)

MPG.PuRe

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Weinert, T.; Olieric, N.; Cheng, R.; Brünle, S.; James, D.; Ozerov, D.; Gashi, D.; Vera, L.; Marsh, M.; Jaeger, K. et al.; Dworkowski, F.; Panepucci, E.; Basu, S.; Skopintsev, P.; Dorè, A. S.; Geng, T.; Cooke, R. M.; Liang, M.; Prota, A. E.; Paneels, V.; Nogly, P.; Ermler, U.; Schertler, G.; Hennig, M.; Steinmetz, M. O.; Wang, M.; Standfuss, J.: Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons. Nature Communications 8, 542 (2017)

MPG.PuRe

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Bai, L.; Wagner, T.; Xu, T.; Hu, X.; Ermler, U.; Shima, S.: A Water-Bridged H-Bonding Network Contributes to the Catalysis of the SAM-Dependent C-Methyltransferase HcgC. Angewandte Chemie, International Edition in English 56 (36), pp. 10806 - 10809 (2017)

MPG.PuRe

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Wagner, T.; Koch, J.; Ermler, U.; Shima, S.: Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction. Science 357 (6352), pp. 699 - 703 (2017)

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Bausewein, T.; Mills, D. J.; Langer, J. D.; Nitschke, B.; Nussberger, S.; Kühlbrandt, W.: Cryo-EM Structure of the TOM Core Complex from Neurospora crassa. Cell 170 (4), pp. 693 - 700 (2017)

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Hau, A.-C.; Grebbin, B. M.; Agoston, Z.; Anders-Maurer, M.; Müller, T.; Groß, A.; Kolb, J.; Langer, J. D.; Döring, C.; Schulte, D.: MEIS homeodomain proteins facilitate PARP1/ARTD1-mediated eviction of histone H1. The Journal of Cell Biology: JCB 216 (9), pp. 2715 - 2729 (2017)

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Bai, L.; Fujishiro, T.; Huang, G.; Koch , J.; Takabayashi, A.; Yokono , M.; Tanaka , A.; Xu, T.; Hu , X.; Ermler, U. et al.; Shima , S.: Towards artificial methanogenesis: biosynthesis of the [Fe]-hydrogenase cofactor and characterization of the semi-synthetic hydrogenase. Faraday Discussions 198 (37), pp. 37 - 58 (2017)

MPG.PuRe

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Kohlstädt, M.; Buschmann, S.; Langer, J. D.; Xie, H.; Michel, H.: Subunit CcoQ is involved in the assembly of the Cbb₃-type cytochrome c oxidases from Pseudomonas stutzeri ZoBell but not required for their activity. Biochimica et Biophysica Acta, Bioenergetics 1858 (3), pp. 231 - 238 (2017)

MPG.PuRe

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Rathmann, B.; Quirnheim Pais, D.; Thielmann, Y.: MPI tray: a versatile crystallization plate for membrane proteins. Journal of Applied Crystallography 50 (1), pp. 327 - 330 (2017)

MPG.PuRe