Hartmut Michel: Molecular Membrane Biology – Department Publications

Lancaster, C. R. D.; Bibikova, M.; Sabatino, P.; Oesterhelt, D.; Michel, H.: Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described at 2.00-A resolution. The Journal of Biological Chemistry 275 (50), pp. 39364 - 39368 (2000)

Roth, A.; Fritz, G.; Büchert, T.; Huber, H.; Stetter, K. O.; Ermler, U.; Kroneck, P. M.H.: Crystallization and preliminary X-ray analysis of adenylylsulfate reductase from Archaeoglobus fulgidus. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen) D56 (12), pp. 1673 - 1675 (2000)

Lancaster, C. R. D.; Groß, R.; Haas, A.; Ritter, M.; Mäntele, W.; Simon, J.; Kröger, A.: Essential role of Glu-C66 for menaquinol oxidation indicates transmembrane electrochemical potential generation by Wolinella succinogenes fumarate reductase. Proceedings of the National Academy of Sciences of the United States of America 97 (24), pp. 13051 - 13056 (2000)

Shima, S.; Thauer, R. K.; Ermler, U.; Durchschlag, H.; Tziatzios, .; Schubert, D.: A mutation affecting the dimer/tetramer association equilibrium of formyltransferase from the hyperthermophilic Methanopyrus kandleri in relation to the activity and thermostability of the enzyme. European Journal of Biochemistry 267 (22), pp. 6619 - 6623 (2000)

Grabarse, W.; Mahlert, F.; Shima , S.; Thauer, R. K.; Ermler, U.: Comparison of three methyl-coenzyme M reductases from phylogenetically distant organisms: unusual amino acid modification, conservation and adaptation. Journal of Molecular Biology (London) 303 (2), pp. 329 - 344 (2000)

Michel, H.: Allowing gene patents could be an expensive mistake for the US. Nature 407, p. 285 - 285 (2000)

Nett, J. H.; Hunte, C.; Trumpower, B. L.: Changes to the length of the flexible linker region of the Rieske protein impair the interaction of ubiquinol with the cytochrome bc₁ complex. European Journal of Biochemistry 267 (18), pp. 5777 - 5782 (2000)

Lancaster, C. R. D.; Kröger, A.: Succinate: quinone oxidoreductases: new insights from X-ray crystal structures. Biochimica et Biophysica Acta, Bioenergetics 1459 (2-3), pp. 422 - 431 (2000)

Shima, S.; Warkentin, E.; Grabarse, W.; Sordel, M.; Wicke, M.; Thauer, R. K.; Ermler, U.: Structure of coenzyme F₄₂₀ dependent methylenetetrahydromethanopterin reductase from two methanogenic archaea. Journal of Molecular Biology (London) 300 (4), pp. 935 - 950 (2000)

Hoffmann, S.; ter Laak , T.; Kühne, R.; Reiländer, H.; Beckers, T.: Residues within Transmembrane Helices 2 and 5 of the Human Gonadotropin-Releasing Hormone Receptor Contribute to Agonist and Antagonist Binding. Molecular Endocrinology 14 (7), pp. 1099 - 1115 (2000)

Hunte, C.; Koepke, J.; Lange, C.; Roßmanith, T.; Michel, H.: Structure at 2.3 Å resolution of the cytochrome bc₁ complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure 8 (6), pp. 669 - 684 (2000)

Pfitzner, U.; Hoffmeier, K.; Harrenga, A.; Kannt, A.; Michel, H.; Bamberg, E.; Ludwig, B.: Tracing the D-Pathway in Reconstituted Site-Directed Mutants of Cytochrome c Oxidase from Paracoccus denitrificans. Biochemistry 39 (23), pp. 6756 - 6762 (2000)

Rengers, J.-U.; Touchard, G.; Decourt, C.; Deret, S.; Michel, H.; Cogné, M.: Heavy and light chain primary structures control IgG3 nephritogenicity in an experimental model for cryocrystalglobulinemia. Blood 95 (11), pp. 3467 - 3472 (2000)

Koepke, J.; Ermler, U.; Warkentin, E.; Wenzl, G.; Flecker, P.: Crystal structure of cancer chemopreventive Bowman-Birk inhibitor in ternary complex with bovine trypsin at 2.3 å resolution. Structural basis of Janus-faced serine protease inhibitor specificity. Journal of Molecular Biology (London) 298 (3), pp. 477 - 491 (2000)

Ruitenberg, M.; Kannt, A.; Bamberg, E.; Ludwig, Bernd; Michel, H.; Fendler, K.: Single-electron reduction of the oxidized state is coupled to proton uptake via the K pathway in Paracoccus denitrificans cytochrome c oxidase. Proceedings of the National Academy of Sciences of the United States of America 97 (9), pp. 4632 - 4636 (2000)

Kuglstatter, A.; Miksovska, J.; Sebban, P.; Fritzsch, G.: Structure of the photosynthetic reaction centre from Rhodobacter sphaeroides reconstituted with anthraquinone as primary quinone Q_A. FEBS Letters (1), pp. 114 - 116 (2000)

Chen, I.-P.; Mathis, P.; Koepke, J.; Michel, H.: Uphill Electron Transfer in the Tetraheme Cytochrome Subunit of the Rhodopseudomonas viridis Photosynthetic Reaction Center:  Evidence from Site-Directed Mutagenesis. Biochemistry 39 (13), pp. 3592 - 3602 (2000)

Arslan, E.; Kannt, A.; Thöny-Meyer, L.; Hennecke, H.: The symbiotically essential cbb₃-type oxidase of Bradyrhizobium japonicum is a proton pump. FEBS Letters 470 (1), pp. 7 - 10 (2000)

Charnock, J. M.; Dreusch, A.; Körner, H.; Neese, F.; Nelson, J.; Kannt, A.; Michel, H.; Garner, C. D.; Kroneck, P. M.H.; Zumft, W. G.: Structural investigations of the Cu_A centre of nitrous oxide reductase from Pseudomonas stutzeri by site-directed mutagenesis and X-ray absorption spectroscopy. European Journal of Biochemistry 267 (5), pp. 1368 - 1381 (2000)

Venturi, M.; Rimons, A.; Gerchman, Y.; Hunte, C.; Padan, E.; Michel, H.: The Monoclonal Antibody 1F6 Identifies a pH-dependent Conformational Change in the Hydrophilic NH₂ Terminus of NhaA Na⁺/H⁺ Antiporter of Escherichia coli. The Journal of Biological Chemistry 271 (7), pp. 4734 - 4742 (2000)

Hampe, W.; Voss, R.-H.; Haase, W.; Boege, F.; Michel, H.; Reiländer, H.: Engineering of a proteolytically stable human β₂-adrenergic receptor/maltose-binding protein fusion and production of the chimeric protein in Escherichia coli and baculovirus-infected insect cells. Journal of Biotechnology 77 (2-3), pp. 219 - 234 (2000)

Selmer, T.; Kahnt, J.; Goubeaud, M.; Shima, S.; Grabarse, W.; Ermler, U.; Thauer, R. K.: The Biosynthesis of Methylated Amino Acids in the Active Site Region of Methyl-coenzyme M Reductase. The Journal of Biological Chemistry 275 (6), pp. 3755 - 3760 (2000)

Behr, J.; Michel, H.; Mäntele, W.; Hellwig, P.: Functional Properties of the Heme Propionates in Cytochrome c Oxidase from Paracoccus denitrificans. Evidence from FTIR Difference Spectroscopy and Site-Directed Mutagenesis. Biochemistry 39 (6), pp. 1356 - 1363 (2000)

Maeda, Y.; Kuroki, R.; Suzuki, H.; Reiländer, H.: High-Level Secretion of Biologically Active Recombinant Human Macrophage Inflammatory Protein-1α by the Methylotrophic Yeast Pichia pastoris. Protein Expression and Purification 18 (1), pp. 56 - 63 (2000)

Harrenga, A.; Reincke, B.; Rüterjans, H.; Ludwig, B.; Michel, H.: Structure of the soluble domain of cytochrome c₅₅₂ from Paracoccus denitrificans in the oxidized and reduced states. Journal of Molecular Biology (London) 295 (3), pp. 667 - 678 (2000)

Schiller, H.; Haase, W.; Molsberger, E.; Janssen, P.; Michel, H.; Reiländer, H.: The human ET(B) endothelin receptor heterologously produced in the methylotrophic yeast Pichia pastoris shows high-affinity binding and induction of stacked membranes. Receptors and Channels 7 (2), pp. 93 - 107 (2000)

Ostermann, T.: Herstellung von Fv-Antikörperfragmenten als Hilfsmittel zur Reinigung und Kokristallisation membranständiger Chinoloxidasen von Escherichia coli und Paracoccus denitrificans. Dissertation, 126 pp., Fachbereich Biochemie, Pharmazie und Lebensmittelchemie, Johann Wolfgang Goethe-Universität, Frankfurt am Main (2000)

Polej, S.: Etablierung einer Camelus bactrianus V_HH-Domänenbibliothek. Isolierung und Charakterisierung von gegen verschiedene Antigene gerichteten Schwerketten-Antikörperfragmenten. Dissertation, 129 pp., Fachbereich Biochemie, Pharmazie und Lebensmittelchemie, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt am Main (2000)

Rengers, J.-U.: Herstellung und Charakterisierung von Antikörpern und Antikörperfragmenten gegen die membranständige Hydrogenase von Wolinella succinogenes. Dissertation, 290 pp., Fachbereich Biochemie, Pharmazie und Lebensmittelchemie, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt am Main (2000)

Venturi, M.: Structural studies of NhaA, the Na⁺/H⁺ antiporter of Escherichia coli, with monoclonal antibodies and their derived Fv and Fab fragments. Dissertation, 143 pp., Fachbereich Chemische und Pharmazeutische Wissenschaften, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt am Main (2000)

Jursa, J.: Heterologe Produktion des humanen P2X₇-Purinozeptors in Baculovirus-infizierten Insektenzellen. Diploma, 94 pp., Fachbereich Biologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main (2000)

Seifert, C.: Herstellung von F_ab-Fragmenten zur Charakterisierungdes Cytochrome bc₁-Komplexes aus Saccharomyces cerevisiae und des Na⁺/H⁺-Austauschers aus Escherichia coli. Diploma, 126 pp., Fachbereich Biochemie, Pharmazie und Lebensmittelchemie, Johann Wolfgang Goethe-Universität, Frankfurt am Main (2000)